KEGG   Homo sapiens (human): 271
Entry
271               CDS       T01001                                 
Symbol
AMPD2, AMPD, PCH9, SPG63
Name
(RefSeq) adenosine monophosphate deaminase 2
  KO
K01490  AMP deaminase [EC:3.5.4.6]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00230  Purine metabolism
hsa01100  Metabolic pathways
hsa01232  Nucleotide metabolism
hsa04820  Cytoskeleton in muscle cells
Module
hsa_M00958  Adenine ribonucleotide degradation, AMP => Urate
Disease
H00266  Hereditary spastic paraplegia
H00897  Pontocerebellar hypoplasia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    271 (AMPD2)
 09140 Cellular Processes
  09142 Cell motility
   04820 Cytoskeleton in muscle cells
    271 (AMPD2)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.6  AMP deaminase
     271 (AMPD2)
SSDB
Motif
Pfam: AMP_deaminase A_deaminase
Other DBs
NCBI-GeneID: 271
NCBI-ProteinID: NP_004028
OMIM: 102771
HGNC: 469
Ensembl: ENSG00000116337
UniProt: Q01433
Structure
Position
1:109619837..109632055
AA seq 825 aa
MASYPSGSGKPKAKYPFKKRASLQASTAAPEARGGLGAPPLQSARSLPGPAPCLKHFPLD
LRTSMDGKCKEIAEELFTRSLAESELRSAPYEFPEESPIEQLEERRQRLERQISQDVKLE
PDILLRAKQDFLKTDSDSDLQLYKEQGEGQGDRSLRERDVLEREFQRVTISGEEKCGVPF
TDLLDAAKSVVRALFIREKYMALSLQSFCPTTRRYLQQLAEKPLETRTYEQGPDTPVSAD
APVHPPALEQHPYEHCEPSTMPGDLGLGLRMVRGVVHVYTRREPDEHCSEVELPYPDLQE
FVADVNVLMALIINGPIKSFCYRRLQYLSSKFQMHVLLNEMKELAAQKKVPHRDFYNIRK
VDTHIHASSCMNQKHLLRFIKRAMKRHLEEIVHVEQGREQTLREVFESMNLTAYDLSVDT
LDVHADRNTFHRFDKFNAKYNPIGESVLREIFIKTDNRVSGKYFAHIIKEVMSDLEESKY
QNAELRLSIYGRSRDEWDKLARWAVMHRVHSPNVRWLVQVPRLFDVYRTKGQLANFQEML
ENIFLPLFEATVHPASHPELHLFLEHVDGFDSVDDESKPENHVFNLESPLPEAWVEEDNP
PYAYYLYYTFANMAMLNHLRRQRGFHTFVLRPHCGEAGPIHHLVSAFMLAENISHGLLLR
KAPVLQYLYYLAQIGIAMSPLSNNSLFLSYHRNPLPEYLSRGLMVSLSTDDPLQFHFTKE
PLMEEYSIATQVWKLSSCDMCELARNSVLMSGFSHKVKSHWLGPNYTKEGPEGNDIRRTN
VPDIRVGYRYETLCQELALITQAVQSEMLETIPEEAGITMSPGPQ
NT seq 2478 nt   +upstreamnt  +downstreamnt
atggcatcctatccatctggctctggcaagcccaaggccaaatatccctttaagaagcgg
gccagcctgcaggcctccactgcagctccagaggctcggggtggtctgggggcccctccg
ctgcagtctgcccgatccctgccgggccccgccccctgcctcaagcacttcccgctcgac
ctgcgcacgtctatggatggcaaatgcaaggagatcgccgaggagctgttcacccgctca
ctggctgagagcgagctccgtagtgccccgtatgagttccccgaggagagccccattgaa
cagctggaggagcggcggcagcggctggagcggcagatcagccaggatgtcaagctggag
ccagacatcctgcttcgggccaagcaagatttcctgaagacggacagtgactcggaccta
cagctctacaaggaacagggtgaggggcagggtgaccggagcctgcgggagcgtgatgtg
ctggaacgggagtttcagcgggtcaccatctctggggaggagaagtgtggggtgccgttc
acagacctgctggatgcagccaagagtgtggtgcgggcgctcttcatccgggagaagtac
atggccctgtccctgcagagcttctgccccaccacccgccgctacctgcagcagctggct
gaaaagcctctggagacccggacctatgaacagggccccgacacccctgtgtctgctgat
gccccggtgcacccccctgcgctggagcagcacccgtatgagcactgtgagccaagcacc
atgcctggggacctgggcttgggtctgcgcatggtgcggggtgtggtgcacgtctacacc
cgcagggaacccgacgagcattgctcagaggtggagctgccataccctgacctgcaggaa
tttgtggctgacgtcaatgtgctgatggccctgattatcaatggccccataaagtcattc
tgctaccgccggctgcagtacctgagctccaagttccagatgcatgtgctactcaatgag
atgaaggagctggccgcccagaagaaagtgccacaccgagatttctacaacatccgcaag
gtggacacccacatccatgcctcgtcctgcatgaaccagaagcatctgctgcgcttcatc
aagcgggcaatgaagcggcacctggaggagatcgtgcacgtggagcagggccgtgaacag
acgctgcgggaggtctttgagagcatgaatctcacggcctacgacctgagtgtggacacg
ctggatgtgcatgcggacaggaacactttccatcgctttgacaagtttaatgccaaatac
aaccctattggggagtccgtcctccgagagatcttcatcaagacggacaacagggtatct
gggaagtactttgctcacatcatcaaggaggtgatgtcagacctggaggagagcaaatac
cagaatgcagagctgcggctctccatttacgggcgctcgagggatgagtgggacaagctg
gcgcgctgggccgtcatgcaccgcgtgcactcccccaacgtgcgctggctggtgcaggtg
ccccgcctctttgatgtgtaccgtaccaagggccagctggccaacttccaggagatgctg
gagaacatcttcctgccactgttcgaggccactgtgcaccctgccagccacccggaactg
catctcttcttagagcacgtggatggttttgacagcgtggatgatgagtccaagcctgaa
aaccatgtcttcaacctggagagccccctgcctgaggcgtgggtggaggaggacaaccca
ccctatgcctactacctgtactacacctttgccaacatggccatgttgaaccacctgcgc
aggcagaggggcttccacacgtttgtgctgaggccacactgtggggaggctgggcccatc
caccacctggtgtcagccttcatgctggctgagaacatttcccacgggctccttctgcgc
aaggcccccgtcctgcagtacctgtactacctggcccagatcggcatcgccatgtctccg
ctcagcaacaacagcctcttcctcagctatcaccggaatccgctaccggagtacctgtcc
cgcggcctcatggtctccctgtccactgatgatcccttgcagttccacttcaccaaggag
ccgctgatggaggagtacagcatcgccacccaggtgtggaagctcagctcctgcgatatg
tgtgagctggcccgcaacagcgtgctcatgagcggcttctcgcacaaggtaaagagccac
tggctgggacccaactataccaaggaaggccctgaggggaatgacatccgccggaccaat
gtgccagacatccgcgtgggctaccgctacgagaccctgtgccaggagctggcgctcatc
acgcaggcagtccagagtgagatgctggagaccattccagaggaggcgggtatcaccatg
agcccagggcctcaatga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (30)   
   KEGG ORTHOLOGY (1)   
   RefGene (12)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (12)   
   OC (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (36)   
   RefSeq(nuc) (6)   
   GenBank (15)   
   EMBL (15)   
3D Structure (4)   
   PDB (4)   
Protein domain (2)   
   Pfam (2)   
All databases (98)   

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